Image-Activated, Assay-Driven Cell Sorting
ODIN revolutionizes cell sorting with its ‘Seeing is Believing’ approach, transforming it from simple intensity peak analysis to a comprehensive, visual journey. It enables real-time, image-based insights, changing how researchers interact with and interpret experiments.
Product Overview
ODIN is a flexible solution that transforms any commercial microscope into a powerhouse for advanced cell sorting and analysis. This cutting-edge tool brings a “Seeing is Believing” ethos to cell sorting, transitioning from traditional intensity peak analysis to a rich, image-based examination. Completely label-free, eliminating the need for staining.
ODIN enables researchers to gain real-time insights into cellular interactions and behaviors, enhancing the understanding of cellular dynamics. Its dual sorting criteria, which incorporate both image-based and optionally fluorescence analysis, significantly reduce false positives and negatives, thereby improving the purity of sorted cell populations. With ODIN, the complexity of cellular functions becomes more accessible, opening new doors for in-depth research and the development of targeted therapies.
ODIN is versatile, supporting a wide range of applications from cell sorting and advanced microfluidics to microrheological measurements. See the table below for more details:
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Image-Activated-Cell-Sorter (IACS) |
Our high-performance, imaging-based next generation cell sorter ODIN enables precise analysis and sorting of droplets, cells, spheroids, microorganisms, algae and other particles. |
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Microfluidic Camera |
Utilize ODIN as a camera for your microfluidic experiments, benefiting from its high-performance software and SmartImaging feature to store only relevant data. Ideal for rare event detection and extended recording times. |
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Droplet Generator |
Effortlessly generate, analyze, and sort droplets with the ODIN system, using its built-in feedback loop to control and manipulate droplet size. |
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Particle Analyzer |
Analyze and sort any type of particle. |
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Microrheology Sensor |
Perform user-friendly particle tracking with the VELOMIR ADD-ON, delivering state-of-the-art precision and speed. Continuously track and record up to 8 particles using a 15-parameter fitting procedure, achieving sub-pixel precision. |
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Imaging Sensor |
High-performance camera with integrated analysis and feature extraction |
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Frame Rate |
210 fps @ 1280×1024 px, up to 10000 fps @ 400×32 px, monochrome, 10bit color depth |
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Sensitivity |
Wavelength range 300-1000 nm, 58% QE @ 550nm peak ; 62% QE @ 630nm; global shutter |
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Readout Regions |
2 freely selectable, simultaneous readout regions, e.g. for two stage processes, immediate quality control or parallelization |
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Latency |
Image capturing to analysis result <200 microseconds, control precision <10 nanoseconds |
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Outputs |
6 flash outputs for light control; 2 trigger for sorting / device control (3.3V TTL) |
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Interfacing |
C-mount; Ethernet; DVI-D; USB |
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Software |
User-friendly and feature-rich graphical user-interface for observation, analysis, and control |
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Analysis |
Real-time analysis of various detection parameters like size, velocity, position, granularity, circumference etc. |
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Gating |
Freely configurable gating; graphical marking in scatter plot; arbitrary points polygon |
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Triggers |
Freely programmable and independent triggers; latency down to 200µs (frame rate dependent) |
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Storage Format |
RAW; AVI uncompressed; MJPEG; MP4; XLS; XLSX; CSV (infinite recording) |
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Multi-Color |
Up to 4 simultaneous imaging settings by time multiplexing (e.g. bright field and three different fluorescent colors) |
Download the full ODIN Specification
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Sorting Method |
Active Dielectrophoretic |
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Sorting Efficiency, Selectivity, Purity |
Up to 99 % demonstrated |
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Droplet Sizes |
10 µm to 1 mm diameter |
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Detection Methods |
Bright field image; Phase contrast image; Fluorescence 408 nm image; Fluorescence 488 nm image; Fluorescence 532 nm image; Fluorescence 561 nm image; Fluorescence 638 nm image |
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Detection Parameters |
Brightness/intensity; brightness contrast; circumference; area; surface roughness; colocalization; fluorescence colocalization; particle count; area contrast; fill factor; elongation; circularity; size; velocity; position; granularity; removal of small dirt particles; area of no contrast; contrast within particles; particles touching walls; particles touching image boundaries; particle position; particle velocity |
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Modular Integration Options |
adaptable sorting techniques; adaptable microfluidic chips (no vendor lock in); adaptable microscope techniques; adaptable lasers; adaptable fluorescence filter sets; adaptable detection technologies; inline droplet generation or reinjection; incubation, temperature control; sterilization |
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Quality Control |
In-line, multispectral image per particle pre & post sorting; all droplets recorded |
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Sample Viability |
Further downstream usage of the sample; maximized cell viability |
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Assay-based Sorting |
Yes |
Download the full ODIN Specification
(Singel) Cell Sorting
(Single) Cell Analysis
Cell Therapy
Drug Discovery
Drop-Seq
(RNA) Sequencing
Bacteria Analysis & Sorting
Algae Analysis & Sorting
Yeast Analysis & Sorting
Particle Analysis & Sorting
Sperm Analysis & Sorting
Spheroid Generation & Sorting
Droplet Generation, Manipulation, Analysis & Sorting
Microfluidic Camera Applications
Microrheological Experiments
Drug-Cell Interaction
Our innovative assay-driven sorting technology identifies cells based on specific drug interactions, offering direct insights into efficacy and mechanisms of action. This breakthrough approach allows you to:
- Develop Patient-Specific Therapeutics: Tailor treatments to individual patient needs for maximum effectiveness.
- Enhance Effectiveness: Improve the precision and impact of therapeutic interventions.
- Accelerate Development: Speed up the process of bringing new treatments to market.
Explore the future of personalized medicine with our cutting-edge solutions
Microbiological Insights
Our advanced technology allows for the direct observation of individual cellular responses, even in unstained cells. Experience the benefits of high sorting speed, maximized cell viability, and sterility.
Biological Research
Our advanced technology enables precise analysis and sorting of microorganisms, facilitating crucial research in antibiotic resistance and pathogen identification.
Pioneering Personalized Medicine
Our technology allows you to sort based on individual cellular responses and isolate high-performing killer cells. Gain insights into cellular functions under various assay conditions, tailor treatments to individual patients, and perform instant, visual quality control. Enjoy the benefits of easy experiment control.
